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VOL. 10, ISSUE 4 (2025)
A comprehensive review on analytical, stability-indicating and In-Vitro evaluation strategies for Paracetamol and Polmacoxib in combined dosage forms
Authors
Rajput Sanjana, Joshi Pooja, Dr. Dipti B Patel, Dr. Deepa Patel, Dr. Ghanshyam Patel
Abstract
Paracetamol and Polmacoxib combination therapy represent an innovative
approach to managing pain and inflammation by combining an
analgesic-antipyretic with a selective COX-2 inhibitor. Analytical method
development and validation play crucial roles in ensuring the accuracy,
precision, and stability of such combined dosage forms. This review highlights
official and non-official analytical methods, stability-indicating studies, and
in-vitro evaluation techniques reported for these drugs individually and
in combination. Literature sources between 2010 and 2025, including
peer-reviewed papers, patents, and regulatory reports, have been critically
analyzed. Special focus is placed on forced degradation studies under acidic,
alkaline, oxidative, photolytic, and thermal stress conditions, as per ICH
Q1A(R2) and Q2(R2) guidelines. The review also discusses the application of
RP-HPLC, UPLC, LC–MS/MS, UV spectroscopy, and green analytical approaches.
Comparative tables summarize method conditions, detection wavelengths, and
validation results. This comprehensive review aims to support formulation scientists
and quality analysts in developing robust and stability-indicating analytical
methods for Paracetamol and Polmacoxib in combined dosage forms.
Pages:53-54
How to cite this article:
Rajput Sanjana, Joshi Pooja, Dr. Dipti B Patel, Dr. Deepa Patel, Dr. Ghanshyam Patel "A comprehensive review on analytical, stability-indicating and <i>In-Vitro</i> evaluation strategies for Paracetamol and Polmacoxib in combined dosage forms". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 4, 2025, Pages 53-54
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