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VOL. 10, ISSUE 4 (2025)
A comprehensive review on analytical, stability-indicating and In-Vitro evaluation strategies for Luliconazole and Salicylic Acid in topical formulations
Authors
Gavli Jagrutiben Kakadbhai, Joshi Pooja, Dr. Deepa R. Patel, Dr. Ganshyam Patel
Abstract
Topical antifungal combinations containing Luliconazole and Salicylic
acid have emerged as efficient options for the management of chronic
dermatophytic infections involving thickened or hyperkeratinized lesions.
Analytical method development and validation ensure formulation quality,
stability, and therapeutic reliability. This review compiles official and
non-official analytical approaches, forced degradation studies, stability-indicating
methods, and in-vitro evaluation strategies applicable to Luliconazole
and Salicylic acid, either alone or in combination. Data from pharmacopoeias,
peer-reviewed publications, patents, and regulatory reports (2010–2025) were
critically examined. Emphasis is placed on ICH Q1A(R2) and Q2(R2) guidelines,
which provide the basis for method validation and stress testing. Analytical
tools such as RP-HPLC, UPLC, LC–MS/MS, UV-Visible spectroscopy, capillary
electrophoresis, and green analytical methodologies are reviewed with
discussion on method optimization, validation parameters, and Quality-by-Design
(QbD) applications. This comprehensive review provides analytical scientists
and formulation developers with consolidated knowledge to establish robust, sensitive,
and regulatory-compliant procedures for Luliconazole–Salicylic acid topical
formulations.
Pages:50-52
How to cite this article:
Gavli Jagrutiben Kakadbhai, Joshi Pooja, Dr. Deepa R. Patel, Dr. Ganshyam Patel "A comprehensive review on analytical, stability-indicating and <i>In-Vitro</i> evaluation strategies for Luliconazole and Salicylic Acid in topical formulations". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 4, 2025, Pages 50-52
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