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VOL. 10, ISSUE 4 (2025)
Bilirubin- Based nanomedicines as emerging antioxidant therapeutics for reactive oxygen species control
Authors
Anil K Masal, Kanchan V Dasharath, Sanjay K Bais
Abstract
Reactive oxygen species (ROS) play a crucial
role in cellular signaling under normal physiological conditions, but their
excessive accumulation is strongly associated with oxidative stress and the
progression of various pathological conditions, including cardiovascular
disorders, neurodegenerative diseases, cancer, and inflammatory syndromes.
Conventional antioxidant therapies often face challenges such as poor
bioavailability, rapid degradation, and limited therapeutic efficacy. In recent
years, bilirubin, a natural end product of heme metabolism with potent
antioxidant and cytoprotective properties, has gained increasing attention as a
therapeutic candidate. However, its hydrophobic nature and instability in
physiological environments restrict its direct clinical application.
Nanomedicine-based strategies have emerged as an effective approach to overcome
these limitations by enhancing bilirubin solubility, stability, targeted
delivery, and controlled release. Bilirubin-loaded or bilirubin-based nanocarriers
not only improve pharmacokinetic profiles but also provide site-specific
therapeutic action, thereby minimizing systemic side effects. This innovative
nanoplatform shows promising potential in mitigating ROS-induced tissue damage
and restoring redox balance in multiple disease models. Overall, bilirubin
nanomedicines represent a novel and versatile therapeutic strategy for managing
ROS-mediated diseases and warrant further translational research to realize
their clinical applicability.
Pages:87-91
How to cite this article:
Anil K Masal, Kanchan V Dasharath, Sanjay K Bais "Bilirubin- Based nanomedicines as emerging antioxidant therapeutics for reactive oxygen species control". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 4, 2025, Pages 87-91
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