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VOL. 10, ISSUE 4 (2025)
Recent advances in the use of polymers for bilayer tablet formulation and drug delivery
Authors
Deepika Gupta, Manju Pandey, Neelkanth M Pujari
Abstract
Bilayer tablets represent an advanced oral
drug-delivery platform designed to incorporate two active pharmaceutical
ingredients (APIs) or two distinct release profiles in a single dosage form.
Polymers play a fundamental role in the structural integrity, release
modulation, stability, and biopharmaceutical performance of bilayer systems.
Recent research has focused on polymer innovation, including novel synthetic
and natural polymers, polymer blends, and smart or stimuli-responsive
materials. Advances in molecular modeling, computational simulations, and
polymer engineering have significantly improved polymer selection and
optimization processes. Additionally, polymer-based strategies—such as
controlled, delayed, targeted, mucoadhesive, and pH-responsive systems—offer
enhanced drug-release precision and patient compliance. Despite their
therapeutic advantages, bilayer tablets face formulation and manufacturing
challenges, including layer separation, mechanical weakness, and stability
issues. Emerging solutions, such as co-processed excipients, hot-melt
extrusion, additive manufacturing, and advanced characterization techniques,
continue to strengthen the reliability of polymer-based bilayer dosage forms.
This review outlines recent progress in polymer science, formulation
strategies, evaluation methods, and future opportunities for polymer-driven
innovation in bilayer tablet technology.
Pages:92-99
How to cite this article:
Deepika Gupta, Manju Pandey, Neelkanth M Pujari "Recent advances in the use of polymers for bilayer tablet formulation and drug delivery". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 4, 2025, Pages 92-99
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