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VOL. 11, ISSUE 1 (2026)
Emerging trends in Niosomal sublingual film drug delivery system
Authors
Sachin Hombale A M, Maruthi N, Pooja B C, G L Yashashwini
Abstract
Sublingual Niosomal films represent a promising drug-delivery platform
designed to enhance the bioavailability and therapeutic performance of
molecules with poor oral absorption or extensive first-pass metabolism. In this
study, niosomes were prepared using non-ionic surfactants and cholesterol via
the thin-film hydration technique and subsequently incorporated into
fast-dissolving polymeric sublingual films. The films were evaluated for
physicochemical properties, including thickness, folding endurance, surface pH,
disintegration time and drug content uniformity. Entrapment efficiency,
particle size and zeta potential of the niosomes were also characterized to
confirm vesicular stability and suitability for transmucosal delivery. Ex vivo
permeation studies demonstrated significantly enhanced drug flux across
sublingual mucosa when compared with conventional films, attributed to the
vesicular structure that facilitates improved drug retention and diffusion. In
vitro release profiling revealed sustained yet rapid-onset release behaviour,
while stability studies confirmed the integrity of both film and niosomal
vesicles over the test period. Overall, the developed sublingual niosomal films
offer a robust, patient-friendly and efficient route for systemic drug
delivery, making them a viable alternative for drugs requiring rapid action and
improved bioavailability.
Pages:1-6
How to cite this article:
Sachin Hombale A M, Maruthi N, Pooja B C, G L Yashashwini "Emerging trends in Niosomal sublingual film drug delivery system". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 11, Issue 1, 2026, Pages 1-6
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