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VOL. 11, ISSUE 1 (2026)
Emerging pyrazole and quinazoline derivatives as bioactive scaffold: Synthesis and pharmacological evaluation
Authors
Pallavi K M, Rashmi T
Abstract
Pyrazole and quinazoline heterocycles have
emerged as privileged scaffolds in medicinal chemistry due to their remarkable
structural versatility and broad spectrum of biological activities. These
frameworks possess favorable electronic and steric properties that enable effective
interactions with a variety of therapeutic targets. This review presents a
comprehensive overview of recent progress in the synthesis and pharmacological
evaluation of pyrazole and quinazoline derivatives. Emphasis is placed on modern
synthetic methodologies, including microwave-assisted, multicomponent, one-pot
and green chemistry approaches, which facilitate the efficient construction of
structurally diverse analogues. Structure activity relationship (SAR) studies
are critically discussed to highlight the impact of substitution patterns on
biological potency and selectivity. Pyrazole and quinazoline derivatives have
demonstrated significant pharmacological activities such as anticancer,
antimicrobial, anti-inflammatory, antiviral, antidiabetic and kinase inhibitory
effects, with particular relevance to targets like epidermal growth factor
receptor (EGFR), cyclooxygenase (COX) and microbial enzymes. Overall, this
review underscores the continued importance of pyrazole and quinazoline
derivatives as key scaffolds in the rational design of next-generation
bioactive agents.
Pages:7-15
How to cite this article:
Pallavi K M, Rashmi T "Emerging pyrazole and quinazoline derivatives as bioactive scaffold: Synthesis and pharmacological evaluation". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 11, Issue 1, 2026, Pages 7-15
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