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VOL. 11, ISSUE 1 (2026)
Pharmacological evaluation of antidepressant activity of Centratherum anthelminticum seed extract
Authors
Anamika Yadav, Yashraj Yadav, Dishant Gupta, Raksha Goswami, Sohan S Chauhan, Rajat Pawar
Abstract
Due to the fact that depression frequently
occur simultaneously and share comparable brain pathways, antidepressants and
anxiety-reducing medications are closely tied to one another. Antidepressants
are the preferred alternative for long-term treatment since they reduce anxiety
over time without the dependence risks associated with anxiolytics.
Anxiolytics, on the other hand, are mostly used for acute or short-term symptom
control. Throughout the course of human history, the utilization of medicinal
plants for the treatment of mental illnesses has been a fact that has
accompanied civilizations. There are several species that have
pharmacologically verified central effects because of their therapeutic
properties. This study next investigated whether or not the seed extract of Centratherum
anthelminticum possessed any possible antidepressant properties. When
compared to the control group, the administration of Centratherum
anthelminticum at a dose of 200 mg/kg resulted in a substantial increase in
the proportion of entry into the open arms in rats. However, this increase was
not observed at a dose of 100 mg/kg. What are the effects of varying doses of
aqueous extract of Centratherum anthelminticum on the number of entry
into the closed arms? When compared to the control group, the results of the
biostatic analysis showed that Cordyline fruticosa significantly increased the
immobility in both tests (FST and TST) at a dose of 200 mg/kg (p < 0.05).
However, this effect was not observed at a dose of 100 mg/kg. It was found, on
the basis of the findings that were presented earlier, that the seed extract of
Centratherum anthelminticum contains powerful depressive effects. Both
the 100 mg/kg and the 200 mg/kg dosing levels of Centratherum anthelminticum
demonstrated antidepressant effects that were statistically significant across
all parameters when compared to the control group.
Pages:44-48
How to cite this article:
Anamika Yadav, Yashraj Yadav, Dishant Gupta, Raksha Goswami, Sohan S Chauhan, Rajat Pawar "Pharmacological evaluation of antidepressant activity of <i>Centratherum anthelminticum</i> seed extract". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 11, Issue 1, 2026, Pages 44-48
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