ARCHIVES
VOL. 11, ISSUE 2 (2026)
UV-spectrophotometric assay of paracetamol in 1% w/v pharmaceutical infusion samples of different marketed brands: A simple and reliable analytical method
Authors
Ousaf Ali, Hitansh Jain, Dr. Narendra Bheemraj Parihar, Dr. Piyush Agarwal
Abstract
Paracetamol (acetaminophen or 4-acetamidophenol) is one of the most widely
used analgesics and antipyretic drugs in pharmaceutical formulations. This
study presents a simple, rapid, and cost-effective UV-spectrophotometric method
for the quantitative determination of paracetamol in 1% w/v pharmaceutical
infusion samples. The method is based on the direct absorbance measurement of
paracetamol in 0.1N sodium hydroxide solution. The developed assay demonstrated
excellent linearity, accuracy, and precision within the acceptable 98-102%
purity range, as defined by pharmacopeial standards. The wavelength of maximum
absorption (λmax) was found to be 256-258 nm. The mean percentage purity of the
test sample was determined to be 100.5%, which falls within the acceptance
criteria. The method has been validated and successfully applied for routine pharmaceutical
analysis. The technique is suitable for quality control in pharmaceutical
laboratories and offers advantages such as simplicity, minimal sample
preparation, rapid analysis, and high reliability. This research contributes to
the standardisation of paracetamol assay procedures in pharmaceutical
formulations.
Pages:14-17
How to cite this article:
Ousaf Ali, Hitansh Jain, Dr. Narendra Bheemraj Parihar, Dr. Piyush Agarwal "UV-spectrophotometric assay of paracetamol in 1% w/v pharmaceutical infusion samples of different marketed brands: A simple and reliable analytical method". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 11, Issue 2, 2026, Pages 14-17
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