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VOL. 11, ISSUE 2 (2026)
Formulation & Evaluation of fast dissolving tablets of Ketotefan fumerate using coprocessed superdisintegrants
Authors
Dushyant Singh, Dr. Rajesh Sharma, Dr. Gurpreet Singh, Dr. G. Jeyabalan, Dr. Praveen Goyal
Abstract
This research involves preparation of mouth
dissolving tablets of Ketotefan fumerate by direct compression method using
various concentrations of co-processed superdisintegrants i.e. Sodium starch
glycolate and crospovidone prepared by different methods viz. Microwave
and Lyophilization. SSG and crospovidone used in different ratio (1:1, 1:2,
1:3, 2:1, 2:2, 2:3, 3:1, 3:2 and 3:3). The tablets were evaluated for
parameters like thickness, hardness, friability, In vitro & In
vivo disintegration time, wetting time, water absorption ratio, % drug
content and In vitro drug release studies. Based on the results, formulation
containing 6% superdisintegrants in combination (CP:SSG = 3:3) (KL-9) was identified
as ideal and better formulation among all formulations developed for Ketotefan
fumerate tablets. In vitro release of optimized formulation of Ketotefan
fumerate Mouth dissolving tablets (KL-9) prepared by lyophilized technology was
found to be 99.89% drug release within 15minutes and in-vitro
disintegration time being ranges between 33-35sec. Though formulation KM-9 also
showed good release (97.02%) prepared by microwave technology but since the
release rate & disintegration profile is comparatively poor hence it is not
selected. Optimized formulation KL-9 showed very good stability profile. From this
observation it was concluded that the formulated tablets of Ketotefan
fumerate (KL-9) were superior, economic and effective in achieving patient
compliance.
Pages:33-38
How to cite this article:
Dushyant Singh, Dr. Rajesh Sharma, Dr. Gurpreet Singh, Dr. G. Jeyabalan, Dr. Praveen Goyal "Formulation & Evaluation of fast dissolving tablets of Ketotefan fumerate using coprocessed superdisintegrants". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 11, Issue 2, 2026, Pages 33-38
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