ARCHIVES
VOL. 11, ISSUE 2 (2026)
Development of novel Sulfathiazole derivatives: Synthesis, spectroscopic characterization, and biological evaluation
Authors
Ahmed Moussa Khalil
Abstract
Sulfathiazole is a sulfonamide antibiotic
scaffold with significant historical therapeutic value and further promise as a
lead structure for novel bioactive. In this study, eight sulfathiazole-based
schiff bases (A1–A8) were synthesized by the condensation reaction of
sulfathiazole with different aldehydes to obtain diversified structural
analogues. The products were solids and the reaction times were 3-5 h. The
reaction products were solids and the reaction time were 3-5.0 h. The products
have a melting point of 243-274°C, which confirms the formation of new
compounds different from the starting materials. Using FT-IR spectroscopy, the
structural identification where Schiff base formation was also reconfirmed by
the presence of typical azomethine (C=N) stretching vibration bands at about
1560-1608 cm-1 together with the presence of characteristic bands
relating to aromatic and substituent group were observed. Antibacterial
activity was checked using Kirby–Bauer disc diffusion for Staphylococcus spp
& Escherichia coli. The parent drug (A0) exhibited the largest inhibition
zone (25 mm), and some representative derivatives displayed diverse activity
(A1:13mm,A2:15 mm, A3:11, A4: 18mm and A5: 17mm), which suggested that
modification of aldehyde could significantly influence the antibacterial
activity. In conclusion the Schiff bases were synthesized, characterized and a
limited number of them exhibited measurable antibacterial activity pointing for
further optimization and quantitative determination of MIC.
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Pages:51-56
How to cite this article:
Ahmed Moussa Khalil "Development of novel Sulfathiazole derivatives: Synthesis, spectroscopic characterization, and biological evaluation". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 11, Issue 2, 2026, Pages 51-56
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