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VOL. 11, ISSUE 2 (2026)
Formulation of an Improved Traditional Medicine (ITM) with antidiabetic and antihypertensive properties in capsules based on the leaves of Bidens pilosa L. (Asteraceae)
Authors
Dzuga Ines1, Djoko Ernest, Tapondjou Azefack Léon, Nguelefack Telesphore Benoit
Abstract
Diabetes and hypertension are major public
health problems worldwide, particularly in developing countries, where
populations are increasingly turning to herbal medicine. However, the
traditional use of plants is largely unsystematic and involves poor preservation
practices. The objective of this study was to formulate an improved traditional
medicine in capsule form based on a dry extract of Bidens pilosa leaves. The
capsule form was chosen for its stability, ease of administration, and ability
to mask the taste. The extract obtained by decoction followed by controlled
drying was a hygroscopic powder. The extraction yield was 17.5%. The total
polyphenol content, determined by the Folin-Ciocalteu method, was 88.56 mg
tannic acid equivalent per gram of extract. The powder was stabilized by the
addition of 2% anhydrous colloidal silica. From a pharmacotechnical standpoint,
the flow rate, Carr's index, and Haussner index were favorable. The recommended
daily dose was 2.43 g of dry extract for a 60 kg individual, divided into six
size 0 capsules for two administrations. These capsules met the requirements of
the European Pharmacopoeia, 11th edition. This study demonstrates the
feasibility of a reproducible pharmaceutical formulation of a plant extract
while preserving its polyphenol content.
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Pages:57-63
How to cite this article:
Dzuga Ines1, Djoko Ernest, Tapondjou Azefack Léon, Nguelefack Telesphore Benoit "Formulation of an Improved Traditional Medicine (ITM) with antidiabetic and antihypertensive properties in capsules based on the leaves of <i>Bidens pilosa</i> L. (Asteraceae)". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 11, Issue 2, 2026, Pages 57-63
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