The aim of this study evaluated the effects aqueous seed extract of Garcinia kola on reproductive performance of male mice. Adult mice (n=30) were included in the present study. The mice were 8 weeks old and weighing 28±3g each. Male mice were kept in standard condition (temperature (25°C) humidity (40-70%) and 12h/12h light/ dark). The experimental animals were divided into control (n=10) and experimental (n=20) groups. The control group just received 8ml distilled water daily. However, the experimental 50gm/Kg/BW and 100gm/Kg/BW of Garcinia kola, for 21 consequence days in water. The present study was showed increasing in body weight 100gm/Kg/BW group and decreasing in50gm/Kg/BW group Garcinia kola -treated group, the testis weight decreased in experimental groups, including 50gm/Kg/BW and 100gm/Kg/BW the Garcinia kola -treated compared with the control group. While were showed that statistically high significant at level (p<0.05) in body, testis weight, sperm counts and sperm motility in all experimental groups, including 50gm/Kg/BW and 100gm/Kg/BW the Garcinia kola -treated compared with the control group. While viability was insignificant difference at level (p>0.05) in group that received 50gm/Kg/BW Garcinia kola when was significant difference at level (p<0.05) in group that received 100gm/Kg/BW Garcinia kola .When the effect of Garcinia kola in sex hormones were significant different (p> 0.05) in FSH; LH and testosterone hormones when compared with control. In case of male mice treated with Garcinia kola daily for 21 days the lumen of the seminiferous tubules showed a significant increased in the luminal spermatozoa.