A article on Glycyrrhiza Glabra, a plant which lost medicinal properties. Beginning of human cultivation plant have been one of the important source of medicinal liquorice is traditional medicinal plant and used in various medicine system. Glycyrrhiza presence of alkaloids, starches, flavonoids, pectin mucilage, steroids. It is mainly used in Ayurvedic medicine various chemical Constituent present in Glycyrrhiza Glabra. In liquorice study indicate antibacterial, antioxidant, Antimalerial, anti-inflammatory and anti-hyper glycemic properties. Most important side effect of liquorice is elevated to blood pressure. It is used for analysed for its total phenolic content and radical scavenging activity. Glycyrrhiza acid mainly found in root of liquorice plant. Glycyrrhiza acid was development in China or Japan as anti-inflammatory, antiviral and anti-allergic drug for lover disease. Different chemical constituent present in G.glabra glycyrrhiza like glycyrrhetic acid, isoliquiritin and isoflavanes etc. Liquorice provide significant protection again various disease and disorder [2, 3, 4, 5].