The liver is an essential organ that aids in the metabolism and elimination of xenobiotics from the body. Liver damage or liver dysfunction, is a serious health issue that concerns not only doctors, but also the pharmaceutical companies and drug regulatory bodies. The effects of numerous hazardous substances (particular antibiotics, chemotherapeutics, carbon tetrachloride (CCl4), thioacetamide (TAA), and microorganisms on liver cells have been extensively researched. Synthetic drugs used to treat liver abnormalities in this condition can also harm the liver in other ways. Synthetic drugs used to treat liver abnormalities in this condition can also harm the liver in other ways. As a result, herbal medications are becoming increasingly popular, and their use is becoming more prevalent. The use of medicinal plants in the treatment of liver illness has a long history. On the market, there are a variety of herbal preparations. The goal of this review is to gather information on prospective phytochemicals from medicinal plants that have been investigated in modern scientific hepatotoxicity models.